1-(Trifluoromethyl)cyclopentanecarboxylic acid

1-(Trifluoromethyl)cyclopentanecarboxylic acid - Names and Identifiers

Name	1-(Trifluoromethyl)cyclopentanecarboxylic acid
Synonyms	1-(Trifluoromethyl)cyclopentanecarboxylic acid 1-(TRIFLUOROMETHYL)CYCLOPENTANE-1-CARBOXYLIC ACID Cyclopentanecarboxylic acid, 1-(trifluoroMethyl)- 1-(trifluoromethyl)cyclopentane-1-carboxylic acid
CAS	277756-44-2
InChI	InChI=1/C7H9F3O2/c8-7(9,10)6(5(11)12)3-1-2-4-6/h1-4H2,(H,11,12)

1-(Trifluoromethyl)cyclopentanecarboxylic acid - Physico-chemical Properties

Molecular Formula	C7H9F3O2
Molar Mass	182.14
Density	1.375±0.06 g/cm3(Predicted)
Melting Point	37-38°C
Boling Point	205.5±35.0 °C(Predicted)
Flash Point	>110℃
Water Solubility	Insoluble in water.
Vapor Presure	0.101mmHg at 25°C
pKa	2.17±0.20(Predicted)
Storage Condition	2-8°C
Refractive Index	1.424
MDL	MFCD08445821

1-(Trifluoromethyl)cyclopentanecarboxylic acid - Risk and Safety

Risk Codes	22 - Harmful if swallowed
UN IDs	UN 2811 6.1/PG 3
WGK Germany	3
Hazard Class	IRRITANT

1-(Trifluoromethyl)cyclopentanecarboxylic acid - Introduction

1-(Trifluoromethyl)cyclopentanecarboxylic acid is an organic compound with the chemical formula C6H9F3O2. The following is a description of its nature, use, preparation and safety information:

Nature:
1-(Trifluoromethyl)cyclopentanecarboxylic acid is a colorless to pale yellow liquid with a pungent odor similar to acid.
It has a density of 1.475g/cm³, a boiling point of 176-178°C (10 mmHg), and a molecular weight of 168.14g/mol.

Use:
1-(Trifluoromethyl)cyclopentanecarboxylic acid is mainly used in the field of organic synthesis. It is often used as an important intermediate in the preparation of esters, amides and other organic compounds. The compound also has certain application value in the pharmaceutical field, and can be used as an important raw material in the field of pesticides.

Method:
The synthesis of 1-(Trifluoromethyl)cyclopentanecarboxylic acid can be achieved by a variety of methods, one of which is the reaction of cyclopentanyl lithium with trifluoroacetic acid chloride. In the course of this reaction, cyclopentanyl lithium is reacted with trifluoroacetic acid chloride to form an intermediate, which is subsequently hydrolyzed to give the desired product.

Safety Information:
1-(Trifluoromethyl)cyclopentanecarboxylic acid is an organic acid that is irritating. General laboratory safety practices are followed, including the wearing of appropriate protective equipment (such as gloves, glasses, and laboratory coats).
In addition, the compound should be stored in a sealed container, protected from light and dry environment, and avoid contact with oxidants, strong acids or strong bases to avoid dangerous reactions. During handling and storage, special care should be taken to prevent contact with water to avoid dangerous corrosion and exothermic reactions.

Last Update：2024-04-10 22:29:15